A STUDY OF FREE RADICAL INJURY TO VITAL ORGANS

نویسندگان

  • ASIF BIN REHMAN From the Department of Pharmacology, Faculty of Pharmacy, University of Karachi
  • IFFAT ZEHRA From the Department of Pharmacology, Faculty of Pharmacy, University of Karachi
  • MOHAMMAD TARIQ AFTAB From the Department of Pharmacology, Faculty of Pharmacy, University of Karachi
  • QAMAR JAMAL the Department of Pathology, Institute of Basic Medical Sciences, Jinnah Post Graduate Medical Center, Karachi, Pakistan.
  • SHAHID RASHID From the Department of Pharmacology, Faculty of Pharmacy, University of Karachi
چکیده مقاله:

The study of toxicities which are caused by free radical inducing chemicals (e.g., carbon tetrachloride), helps to determine the mode of action of those important drugs which act by inhibiting free radicals. Evaluation of toxicities induced by carbon tetrachloride and phenobarbitone administration was carried out in seventy healthy male rabbits. Each animal received CCI4 0.25-0.5 mL/kg body weight, intraperitoneally, twice weekly for eleven doses. During this period, the only water which was provided for drinking to these animals contained 0.25 g/L pentobarbitone. Examination of these animals revealed that carbon tetrachloride produced severe liver and kidney injuries which could be assessed by physical parameters, liver and kidney function tests, and microscopic .examinations of the vital organs of these aninlals.

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a study of free radical injury to vital organs

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عنوان ژورنال

دوره 9  شماره 2

صفحات  131- 136

تاریخ انتشار 1995-08

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